Frequency not defined. Dermatologic: Dry skin, pruritus, peeling, erythema, sunburn, redness, burning
Postmarketing and/or case reports: Colitis, diarrhea, pseudomembranous colitis
Erythromycin: Concurrent use may lead to antagonism of antimicrobial effects of clindamycin.
Tretinoin: Increases adverse reactions with concurrent use.
BenzaClin®: Store at room temperature of 25°C (77°F); do not freeze. Reconstitute clindamycin with purified water; shake well. Add solution to benzoyl peroxide gel and stir until homogenous in appearance. Discard unused portion after 2 months.
Duac™: Prior to dispensing, store in refrigerator, between 2°C to 8°C (36°F to 46°F). Once dispensed, may be stored by patient at room temperature of up to 25°C (77°F) if used within 60 days. Do not freeze.
See individual agents. Absorption: Benzoyl peroxide: <2% systemically absorbed
Metabolism: Benzoyl peroxide: Converted to benzoic acid in the skin
Topical: Children 
12 years and Adults: Apply to affected areas after skin has been cleansed and dried BenzaClin®: Acne: Apply twice daily (morning and evening)
Duac™: Inflammatory acne: Apply once daily in the evening
Gel, topical: BenzaClin®: Clindamycin phosphate 1% and benzoyl peroxide 5% (25 g, 50 g)
Duac™: Clindamycin phosphate 1% and benzoyl peroxide 5% (45 g)
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